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Literature summary extracted from

  • Hongo, A.; Gu, R.; Suzuki, M.; Nemoto, N.; Nishigaki, K.
    A radioisotope-nondependent high-sensitivity method for measuring the activity of glioblastoma-related O6-methylguanine DNA methyltransferase (2015), Anal. Biochem., 480, 82-84.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.63 O6-benzylguanine
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.63 DNA (containing 6-O-methylguanine) + protein L-cysteine Homo sapiens
-
 DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.63 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.63 A-431 cell
-
 Homo sapiens
-
2.1.1.63 glioblastoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.63 DNA (containing 6-O-methylguanine) + protein L-cysteine
-
 Homo sapiens DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.63 MGMT
-
 Homo sapiens
2.1.1.63 O6-methylguanine DNA methyltransferase
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.1.1.63 0.0004
-
 at pH 7.5 and 37°C Homo sapiens O6-benzylguanine